Synbiotics 200

• Design: 596 participants, 6-week double-blind virtual randomized controlled trial
• Population: Adults experiencing occasional digestive discomfort
• Dosage: 200mg ButyraGen® tributyrin daily
• Primary Outcomes:
  • 18% reduction in abdominal pain intensity vs. placebo (statistically significant)
  • 15% reduction in gas and bloating symptoms, particularly pronounced in female participants
  • Improvements in overall digestive comfort scores across multiple validated assessment tools
• Timeline:
  • Initial relief observed starting at week 2 of supplementation
  • Benefits sustained and continued to improve through week 6
  • No tolerance development—effects remained consistent throughout study period
• Safety Profile: Excellent tolerability with minimal side effects, significantly lower GI complaints compared to high-dose prebiotic fiber interventions
• Clinical Significance: This large participant pool demonstrates real-world effectiveness for gentle digestive comfort without the common side effects associated with traditional fiber supplements (gas, bloating, cramping). The rapid onset of benefits (2 weeks) makes this clinically relevant for consumers seeking timely relief.
• Published: Nutrition research databases (cdn.nutrition.org)

• Design: 24 participants, 21-day prospective clinical trial
• Population: Healthy adults without pre-existing inflammatory conditions
• Dosage: 200mg ButyraGen® daily
• Safety Results:
  • Well-tolerated with <10% of participants reporting mild, transient GI complaints
  • No serious adverse events reported
  • No clinically significant changes in vital signs or laboratory values
  • Compliance rate >95%, indicating ease of daily use
• Anti-Inflammatory Findings:
  • Trending reduction in high-sensitivity C-reactive protein (hs-CRP), a key systemic inflammation marker
  • Participants with baseline elevated inflammation showed more pronounced improvements
  • Suggests potential metabolic and cardiovascular benefits beyond gut health
• Mechanistic Insights: Butyrate's known anti-inflammatory properties were reflected in systemic markers, supporting the hypothesis that gut-derived butyrate influences whole-body inflammation
• Clinical Significance: Confirms ButyraGen® is safe for daily long-term use while providing preliminary evidence of systemic health benefits. The anti-inflammatory findings open possibilities for metabolic health applications beyond digestive support.

• Design: In vitro human colon fermentation model (SHIME® system - Simulator of Human Intestinal Microbial Ecosystem)
• Comparison Groups: ButyraGen® 200mg vs. Inulin 4g vs. ButyraGen® + L. rhamnosus GG probiotic
• Key Findings:
  • Equivalent Output: 200mg ButyraGen® produced the same amount of butyrate as 4,000mg (4g) of inulin prebiotic fiber
  • Dose Efficiency: This represents a 20:1 concentration advantage—delivering maximum butyrate support without requiring 8× more capsules
  • Synbiotic Synergy: When ButyraGen® was combined with L. rhamnosus GG probiotic strain, butyrate production more than doubled compared to probiotic alone
  • Sustained Production: Unlike single-dose butyrate supplements that absorb quickly in the upper GI tract, ButyraGen®'s Sunfiber® matrix enabled sustained butyrate generation throughout the entire colon
  • Microbiome Impact: The combination enhanced populations of butyrate-producing bacteria (Faecalibacterium, Roseburia), creating a positive feedback loop for ongoing butyrate synthesis
• Clinical Implications:
  • Eliminates the need for high-dose fiber supplementation that often causes gas, bloating, and requires multiple large capsules
  • Demonstrates true synbiotic effect—prebiotics, probiotics, and postbiotics working synergistically rather than just coexisting in a formula
  • Validates our 3-in-1 approach: the prebiotics feed the probiotics, which enhance ButyraGen®'s conversion to butyrate
• Published: SAGE Journals, Nutrition Research databases

ButyraGen® utilizes a patented dual-release mechanism optimized for maximum butyrate delivery throughout the entire digestive tract:

Phase 1 - Small Intestine (Immediate Release):

• Pancreatic lipase enzymes cleave the tributyrin molecule into three individual butyrate molecules
• These free butyrate molecules are immediately available for absorption by small intestinal cells
• Provides rapid support for intestinal barrier function and local anti-inflammatory effects
• This immediate-release component differentiates ButyraGen® from standard butyric acid supplements that can cause unpleasant odor

Phase 2 - Large Intestine (Sustained Release):

• The Sunfiber® (partially hydrolyzed guar gum) carrier matrix reaches the colon intact
• Beneficial bacteria ferment the Sunfiber®, generating additional butyrate production
• This sustained release ensures butyrate availability for colonocytes (colon lining cells) where it's most needed
• Creates an optimal environment for butyrate-producing bacteria to thrive

Synergistic Enhancement: When combined with our 30-strain probiotic blend (particularly Lactobacillus and Bifidobacterium species), ButyraGen®'s effectiveness multiplies. The probiotics enhance fermentation efficiency, increase butyrate yield, and support a healthier gut environment that naturally produces more short-chain fatty acids.

Why Butyrate Matters: Butyrate is the preferred energy source for colonocytes (cells lining your colon), providing up to 70% of their energy needs. Beyond cellular fuel, butyrate strengthens tight junctions between intestinal cells (reducing "leaky gut"), modulates immune responses, supports healthy inflammation levels, and has been shown to influence metabolic health, brain function, and even mood regulation through the gut-brain axis.

The ButyraGen® Advantage: Traditional approaches to increasing butyrate require consuming 15-20g of fermentable fiber daily, which often causes significant gas, bloating, and digestive discomfort—ironically, the very symptoms people are trying to resolve. ButyraGen®'s concentrated tributyrin complex delivers therapeutic butyrate levels in just 200mg, making it practical for daily use without the bulk or side effects of high-dose fiber protocols.